Source:http://linkedlifedata.com/resource/pubmed/id/21558387
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2011-5-17
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| pubmed:abstractText |
Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It remains unclear, however, whether such genetic variants are associated with disease aggressiveness--one of the most important questions in prostate cancer research today. To help clarify this and substantially expand research in the genetic determinants of prostate cancer aggressiveness, the first National Cancer Institute Prostate Cancer Genetics Workshop assembled researchers to develop plans for a large new research consortium and patient cohort. The workshop reviewed the prior work in this area and addressed the practical issues in planning future studies. With new DNA sequencing technology, the potential application of sequencing information to patient care is emerging. The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1538-7445
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| pubmed:author |
pubmed-author:Bailey-WilsonJoan EJE,
pubmed-author:CampNicola JNJ,
pubmed-author:CatalonaWilliam JWJ,
pubmed-author:ChanockStephen JSJ,
pubmed-author:CooneyKathleen AKA,
pubmed-author:EastonDouglas FDF,
pubmed-author:EelesRosalind ARA,
pubmed-author:FitzGeraldLiesel MLM,
pubmed-author:FreedmanMatthew LML,
pubmed-author:GudmundssonJuliusJ,
pubmed-author:IsaacsWilliam BWB,
pubmed-author:KittlesRick ARA,
pubmed-author:MarguliesElliott HEH,
pubmed-author:McGuireBarry BBB,
pubmed-author:OstranderElaine AEA,
pubmed-author:RebbeckTimothy RTR,
pubmed-author:StanfordJanet LJL,
pubmed-author:ThibodeauStephen NSN,
pubmed-author:WitteJohn SJS
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| pubmed:copyrightInfo |
©2011 AACR
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
71
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3442-6
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| pubmed:dateRevised |
2011-10-27
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| pubmed:meshHeading |
pubmed-meshheading:21558387-Computational Biology,
pubmed-meshheading:21558387-Ethnic Groups,
pubmed-meshheading:21558387-Genetic Predisposition to Disease,
pubmed-meshheading:21558387-Genotype,
pubmed-meshheading:21558387-Humans,
pubmed-meshheading:21558387-Male,
pubmed-meshheading:21558387-National Cancer Institute (U.S.),
pubmed-meshheading:21558387-National Institutes of Health (U.S.),
pubmed-meshheading:21558387-Polymorphism, Single Nucleotide,
pubmed-meshheading:21558387-Prostatic Neoplasms,
pubmed-meshheading:21558387-Sequence Analysis, DNA,
pubmed-meshheading:21558387-United States
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| pubmed:year |
2011
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| pubmed:articleTitle |
National Cancer Institute Prostate Cancer Genetics Workshop.
|
| pubmed:affiliation |
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. wcatalona@nmff.org
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| pubmed:publicationType |
Congresses,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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