Linked Life Data

21558321

Source:http://linkedlifedata.com/resource/pubmed/id/21558321

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-7-4
pubmed:abstractText
The p38 mitogen-activated protein kinase (p38MAPK) signal transduction pathway is an important regulator of cell processes, whose deregulation leads to the development and progression of cancer. Defining the role of each p38MAPK family member in these processes has been difficult. To date, most studies of the p38MAPK pathways focused on function of the p38? isoform, which is widely considered to negatively regulate malignant transformation; nonetheless, few reports address the p38? and p38? isoforms. Here, we used embryonic fibroblasts derived from mice lacking p38? or p38? and show evidence that these isoforms participate in several processes involved in malignant transformation. We observed that lack of either p38? or p38? increased cell migration and metalloproteinase-2 secretion, whereas only p38? deficiency impaired cell contact inhibition. In addition, lack of p38? in K-Ras-transformed fibroblasts led to increased cell proliferation as well as tumorigenesis both in vitro and in vivo. Our results indicate that p38? and p38? have a role in the suppression of tumor development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1460-2180
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1093-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Evidence of p38? and p38? involvement in cell transformation processes.
pubmed:affiliation
Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, 28049 Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't