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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-4-25
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pubmed:abstractText |
Long-term pretreatment of rat mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulated protein kinase C activity and potentiated the angiotensin II-induced inositol trisphosphate (InsP3) formation. This increased response to angiotensin II occurred without a significant change in the receptor number or Kd value of angiotensin II binding to the cells. The biologically inactive phorbol ester 4 alpha-phorbol 12,13-didecanoate was without effect on angiotensin II-stimulated InsP3 generation. Long-term pretreatment with TPA also increased the angiotensin II-induced mobilization of Ca2+ and the subsequent contraction of mesangial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
261
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-11
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2155825-Angiotensin II,
pubmed-meshheading:2155825-Animals,
pubmed-meshheading:2155825-Calcium,
pubmed-meshheading:2155825-Down-Regulation,
pubmed-meshheading:2155825-Drug Synergism,
pubmed-meshheading:2155825-Glomerular Mesangium,
pubmed-meshheading:2155825-Hydrolysis,
pubmed-meshheading:2155825-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:2155825-Inositol Phosphates,
pubmed-meshheading:2155825-Kinetics,
pubmed-meshheading:2155825-Muscle Contraction,
pubmed-meshheading:2155825-Phosphatidylinositols,
pubmed-meshheading:2155825-Protein Kinase C,
pubmed-meshheading:2155825-Rats,
pubmed-meshheading:2155825-Tetradecanoylphorbol Acetate
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pubmed:year |
1990
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pubmed:articleTitle |
Potentiation of angiotensin II-stimulated phosphoinositide hydrolysis, calcium mobilization and contraction of renal mesangial cells upon down-regulation of protein kinase C.
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pubmed:affiliation |
Ciba-Geigy Ltd, Pharmaceuticals Division, Basel, Switzerland.
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pubmed:publicationType |
Journal Article
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