Linked Life Data

21557068

Source:http://linkedlifedata.com/resource/pubmed/id/21557068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-5-10
pubmed:abstractText
Extracellular adhesins frequently compose large, highly-ordered structural assemblies that project away from the bacterial surface. These assemblies, known as pili or fimbriae, are rod-like polymeric structures that in some cases can extend up to several micrometers from the cell surface. Because these adhesin structures are critical to bacterial colonization of host cell surfaces, there is an incentive to understand their structure, assembly and mechanism of host cell attachment. Various methods in Nuclear Magnetic Resonance (NMR) spectroscopy have been used to address these topics, yielding structural information at the atomic level. Also, new methods in solid-state NMR spectroscopy have thus far been under-utilized in the study of large adhesin structures and offer a powerful approach to overcoming problems with crystallization to better understand the structures of these complexes. The following is a brief overview of the contributions of NMR to the study of bacterial adhesins with an emphasis on the future potential of solid-state NMR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
715
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-56
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The application of NMR techniques to bacterial adhesins.
pubmed:affiliation
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. frank.shewmaker@usuhs.mil
pubmed:publicationType
Journal Article, Review