Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1990-4-16
|
| pubmed:abstractText |
One hundred forty-nine patients with localized nonsmall cell carcinoma of the lung (Stage III A and B) were treated with two monthly cycles of initial chemotherapy that included vindesine-cisplatin followed by 6000 cGy of thoracic irradiation. Patients with complete, partial, and minor response after initial chemotherapy were randomized into groups to receive either maintenance chemotherapy (four cycles) after radiotherapy or radiotherapy alone. The objective response rate was 24% after chemotherapy and 41% after combined chemoradiotherapy (complete response, 7.5%). The overall median survival was 9 months and the 2-year survival was 14%. Survival was identical with or without maintenance chemotherapy. The 2-year survival of patients with complete response was 75% compared with 9% for patients with partial or minor response. These results suggest that only the few patients (ten) who achieve complete response have a strong probability of survival. It is therefore essential to search for other therapeutic modalities that result in an increase of the complete response rate.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0008-543X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1472-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2155697-Adult,
pubmed-meshheading:2155697-Aged,
pubmed-meshheading:2155697-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2155697-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:2155697-Cause of Death,
pubmed-meshheading:2155697-Cisplatin,
pubmed-meshheading:2155697-Combined Modality Therapy,
pubmed-meshheading:2155697-Drug Administration Schedule,
pubmed-meshheading:2155697-Female,
pubmed-meshheading:2155697-Humans,
pubmed-meshheading:2155697-Incidence,
pubmed-meshheading:2155697-Lung Neoplasms,
pubmed-meshheading:2155697-Male,
pubmed-meshheading:2155697-Middle Aged,
pubmed-meshheading:2155697-Neoplasm Staging,
pubmed-meshheading:2155697-Prospective Studies,
pubmed-meshheading:2155697-Radiation Injuries,
pubmed-meshheading:2155697-Randomized Controlled Trials as Topic,
pubmed-meshheading:2155697-Respiration Disorders,
pubmed-meshheading:2155697-Survival Rate,
pubmed-meshheading:2155697-Vindesine
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Two cycles of cisplatin-vindesine and radiotherapy for localized nonsmall cell carcinoma of the lung (stage III). Results of a prospective trial with 149 patients.
|
| pubmed:affiliation |
Department of Oncology/Hematology, Laennec Hospital, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|