Linked Life Data

21555505

Source:http://linkedlifedata.com/resource/pubmed/id/21555505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-5-10
pubmed:abstractText
In the US, patients who initiate dialysis "early" (at Modification of Diet in Renal Disease estimated GFR [eGFR]> 10 ml/min per 1.73 m(2)) account for over 50 percent of new dialysis starts. This trend to an early start is based on conventional wisdoms regarding benefits of dialytic clearance, that albumin levels are nutritional markers, and early dialytic therapy is justified to improve nutrition especially in diabetics and that waiting until low levels of eGFR (i.e., <6 ml/min per 1.73 m(2)) may be dangerous. In order to justify early dialysis treatment, the therapy must provide a morbidity, mortality, or quality of life benefit. The current review examines whether early dialysis initiation provides any of these benefits and whether the conventional wisdoms that have promoted this early dialysis trend are valid. Utilizing this information and the results of recent large observational studies and the randomized controlled Initiating Dialysis Early and Late (IDEAL) study, we suggest that dialysis initiation is justified at GFR levels of 5-9 ml/min/1.73 m(2), if accompanied by uremia symptoms or fluid management issues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1555-905X
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 by the American Society of Nephrology
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1222-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Early start of dialysis: a critical review.
pubmed:affiliation
Dorn Research Institute, William Jennings Bryan Dorn Veterans Hospital, University of South Carolina, Arnold School of Public Health, Columbia, South Carolina 29206, USA. sjrcra@yahoo.com
pubmed:publicationType
Journal Article, Review