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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2011-5-25
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pubmed:abstractText |
A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A? (hnps-PLA?) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA? inhibition activity in the in vitro bioassay. The IC?? value for the best compound 3o was 1.5 ?M. The structure-inhibition-activity relationships of the compounds were studied using molecular docking.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:copyrightInfo |
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3361-6
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A? inhibitors.
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pubmed:affiliation |
BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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