Source:http://linkedlifedata.com/resource/pubmed/id/21551945
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-5-9
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| pubmed:abstractText |
Intracellular vesicle trafficking is the principal transportation system in eukaryotic cells, and is considered to be involved in a variety of processes related to cell proliferation. A protein named alpha-taxilin has been identified as a binding partner of the syntaxin family, which coordinates intracellular vesicle trafficking. To clarify the role of alpha-taxilin in renal cell carcinoma (RCC), we investigated alpha-taxilin protein expression in clear cell RCC tissues. We analyzed alphataxilin protein in matched sets of tumor and non-tumor tissues from the surgical specimens of 52 Japanese RCC patients by Western blotting. We also studied the relation between alpha-taxilin protein expression in tumor tissues and various clinicopathological features. The alpha-taxilin protein level was higher in tumor tissues than in non-tumor tissues (P < 0.05). Increased expression of alpha-taxilin protein in primary tumors was related to local invasion (P < 0.001), pathological vessel invasion (P < 0.001), and metastasis (P < 0.0001). Kaplan-Meier plots of survival for patients with low versus high alpha-taxilin expression revealed that high expression in tumor tissues was associated with shorter overall survival in all patients (P < 0.05) and with shorter disease-free survival in patients without metastasis (P < 0.01). These findings suggest that alpha-taxilin influences the metastatic and invasive potential of RCC.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Qa-SNARE Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TXLNA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1880-313X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
32
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
103-10
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| pubmed:meshHeading |
pubmed-meshheading:21551945-Aged,
pubmed-meshheading:21551945-Asian Continental Ancestry Group,
pubmed-meshheading:21551945-Blotting, Western,
pubmed-meshheading:21551945-Carcinoma, Renal Cell,
pubmed-meshheading:21551945-Cell Proliferation,
pubmed-meshheading:21551945-Disease-Free Survival,
pubmed-meshheading:21551945-Female,
pubmed-meshheading:21551945-Gene Expression,
pubmed-meshheading:21551945-Humans,
pubmed-meshheading:21551945-Kaplan-Meier Estimate,
pubmed-meshheading:21551945-Kidney Neoplasms,
pubmed-meshheading:21551945-Male,
pubmed-meshheading:21551945-Middle Aged,
pubmed-meshheading:21551945-Neoplasm Invasiveness,
pubmed-meshheading:21551945-Prognosis,
pubmed-meshheading:21551945-Qa-SNARE Proteins,
pubmed-meshheading:21551945-Tumor Markers, Biological,
pubmed-meshheading:21551945-Vesicular Transport Proteins
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
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| pubmed:affiliation |
Department of Urology, Dokkyo Medical University, Mibu, Tochigi, Japan.
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| pubmed:publicationType |
Journal Article
|