| pubmed-article:21551231 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C1515126 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C1417768 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21551231 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21551231 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:21551231 | pubmed:dateCreated | 2011-7-1 | lld:pubmed |
| pubmed-article:21551231 | pubmed:abstractText | Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly understood. The present study investigated microRNAs involved in human thymocyte differentiation by comparing the microRNA expression profiles of thymocytes at the double-positive, single-positive CD4(+) and single-positive CD8(+) maturation stages. Microarray analysis showed that each thymocyte population displays a distinct microRNA expression profile that reflects their developmental relationships. Moreover, analysis of small-RNA libraries generated from human unsorted and double-positive thymocytes and from mature peripheral CD4(+) and CD8(+) T lymphocytes, together with the microarray data, indicated a trend toward up-regulation of microRNA expression during T-cell maturation after the double-positive stage and revealed a group of microRNAs regulated during normal T-cell development, including miR-150, which is strongly up-regulated as maturation progresses. We showed that miR-150 targets NOTCH3, a member of the Notch receptor family that plays important roles both in T-cell differentiation and leukemogenesis. Forced expression of miR-150 reduces NOTCH3 levels in T-cell lines and has adverse effects on their proliferation and survival. Overall, these findings suggest that control of the Notch pathway through miR-150 may have an important impact on T-cell development and physiology. | lld:pubmed |
| pubmed-article:21551231 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21551231 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21551231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21551231 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21551231 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21551231 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:BronteVincenz... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:ZanovelloPaol... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:StellinGiovan... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:IndraccoloSte... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:AmadoriAlbert... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:BassoGiuseppe... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:GerosaGinoG | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:GuffantiAless... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:D'AgostinoDon... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:BassoKatiaK | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:MussolinLaraL | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:FrassonChiara... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:GhisiMargheri... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:CorradinAlber... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:SerafinValent... | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:RuggeroKatiaK | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:BonannoLauraL | lld:pubmed |
| pubmed-article:21551231 | pubmed:author | pubmed-author:MukherjeeSubh... | lld:pubmed |
| pubmed-article:21551231 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21551231 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:21551231 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:21551231 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21551231 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21551231 | pubmed:pagination | 7053-62 | lld:pubmed |
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| pubmed-article:21551231 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21551231 | pubmed:articleTitle | Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150. | lld:pubmed |
| pubmed-article:21551231 | pubmed:affiliation | Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy. | lld:pubmed |
| pubmed-article:21551231 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21551231 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21551231 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21551231 | lld:entrezgene |
