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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2011-5-25
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pubmed:abstractText |
Further exploration around the recently disclosed potent triple re-uptake inhibitor 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane led to the identification of a new series of potent triple re-uptake inhibitors endowed with good developability characteristics. The insertion of a further aryl moiety into the template allowed the 'titration' of the SERT/NET/DAT ratio leading to the identification of further tools in this important area.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:BettatiMichelaM,
pubmed-author:BonanomiGiorgioG,
pubmed-author:CavanniPaoloP,
pubmed-author:Di FabioRomanoR,
pubmed-author:FazzolariElettraE,
pubmed-author:MarchioroCarlaC,
pubmed-author:MicheliFabrizioF,
pubmed-author:RoscicMajaM,
pubmed-author:TarsiLucaL,
pubmed-author:VisentiniFilippoF,
pubmed-author:WorbyAngelaA,
pubmed-author:ZonziniLauraL
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3451-61
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pubmed:meshHeading |
pubmed-meshheading:21550808-Adrenergic Uptake Inhibitors,
pubmed-meshheading:21550808-Aza Compounds,
pubmed-meshheading:21550808-Bicyclo Compounds,
pubmed-meshheading:21550808-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:21550808-Dopamine Uptake Inhibitors,
pubmed-meshheading:21550808-Heptanes,
pubmed-meshheading:21550808-Humans,
pubmed-meshheading:21550808-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:21550808-Protein Binding,
pubmed-meshheading:21550808-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:21550808-Serotonin Uptake Inhibitors,
pubmed-meshheading:21550808-Structure-Activity Relationship
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pubmed:year |
2011
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pubmed:articleTitle |
1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.
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pubmed:affiliation |
GlaxoSmithKline Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy. fabrizio.micheli@aptuit.com
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pubmed:publicationType |
Journal Article
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