Source:http://linkedlifedata.com/resource/pubmed/id/21550580
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-7-15
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| pubmed:abstractText |
Chronic hypertension is a major concern in adults who have undergone resection of coarctation of the aorta (CoA) in childhood. In otherwise healthy subjects, exercise-induced hypertension is prognostic for chronic hypertension; however, the prognostic value in patients with CoA remains unknown. The aim of the present study was to evaluate the predictive value of exercise-induced hypertension for chronic hypertension in these patients. In the present prospective follow-up study, 74 patients with CoA (58% men, age 30.9 ± 9.5 years) underwent ambulatory blood pressure (BP) monitoring and exercise testing twice from 2001 to 2009 with a follow-up period of 6.3 ± 0.8 years. Hypertension was defined as a mean systolic BP ?140 mm Hg and/or mean diastolic BP ?90 mm Hg or the need for antihypertensive treatment. Exercise-induced hypertension was defined as a mean systolic BP of <140 mm Hg and peak exercise systolic BP of ?200 mm Hg. At baseline, 27 patients (36%) were hypertensive, 11 (15%) had exercise-induced hypertension, and 36 (49%) were normotensive. At follow-up, all 27 hypertensive patients remained hypertensive. Of the 11 with exercise-induced hypertension, 7 (64%) had developed chronic hypertension, and 4 (36%) continued to have exercise-induced hypertension. Of the 36 normotensive patients, 7 (19%) had developed hypertension, 12 (33%) had developed exercise-induced hypertension, and 17 (47%) remained normotensive. On multivariate analysis, baseline maximum exercise systolic BP was independently associated with the mean systolic BP at follow-up (? = 0.13, p = 0.005). In conclusion, the maximum exercise systolic BP was a predictor for chronic hypertension in patients with CoA. These findings demonstrate the clinical importance of exercise-induced hypertension and warrant additional study into the long-term consequences of exercise-induced hypertension and the potential beneficial role of early antihypertensive treatment in adult patients after CoA repair with exercise-induced hypertension.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1879-1913
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
108
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
435-9
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| pubmed:meshHeading |
pubmed-meshheading:21550580-Adult,
pubmed-meshheading:21550580-Anastomosis, Surgical,
pubmed-meshheading:21550580-Aorta, Thoracic,
pubmed-meshheading:21550580-Aortic Coarctation,
pubmed-meshheading:21550580-Aortic Valve,
pubmed-meshheading:21550580-Aortic Valve Stenosis,
pubmed-meshheading:21550580-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:21550580-Chronic Disease,
pubmed-meshheading:21550580-Echocardiography,
pubmed-meshheading:21550580-Exercise Test,
pubmed-meshheading:21550580-Female,
pubmed-meshheading:21550580-Follow-Up Studies,
pubmed-meshheading:21550580-Humans,
pubmed-meshheading:21550580-Hypertension,
pubmed-meshheading:21550580-Hypertrophy, Left Ventricular,
pubmed-meshheading:21550580-Male,
pubmed-meshheading:21550580-Multivariate Analysis,
pubmed-meshheading:21550580-Netherlands,
pubmed-meshheading:21550580-Postoperative Complications,
pubmed-meshheading:21550580-Predictive Value of Tests,
pubmed-meshheading:21550580-Prospective Studies,
pubmed-meshheading:21550580-Recurrence,
pubmed-meshheading:21550580-Registries,
pubmed-meshheading:21550580-Reoperation,
pubmed-meshheading:21550580-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood.
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| pubmed:affiliation |
Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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