|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2011-5-20
|
|
pubmed:abstractText |
A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:Alvarez-SánchezRubénR,
pubmed-author:AouraTT,
pubmed-author:BenardeauAgnesA,
pubmed-author:BenzJörgJ,
pubmed-author:GublerMarcelM,
pubmed-author:HaapWolfgangW,
pubmed-author:HebeisenPaulP,
pubmed-author:JosephCatherineC,
pubmed-author:KirchnerStephanS,
pubmed-author:KitasEricE,
pubmed-author:KuhnBerndB,
pubmed-author:MohrPeterP,
pubmed-author:SchottBrigitteB,
pubmed-author:TozzoEffieE,
pubmed-author:WesselHans PeterHP,
pubmed-author:ZutterUlrichU
|
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3237-42
|
|
pubmed:meshHeading |
pubmed-meshheading:21550236-Administration, Oral,
pubmed-meshheading:21550236-Allosteric Site,
pubmed-meshheading:21550236-Aminopyridines,
pubmed-meshheading:21550236-Animals,
pubmed-meshheading:21550236-Crystallography, X-Ray,
pubmed-meshheading:21550236-Diabetes Mellitus, Type 2,
pubmed-meshheading:21550236-Disease Models, Animal,
pubmed-meshheading:21550236-Enzyme Activation,
pubmed-meshheading:21550236-Enzyme Inhibitors,
pubmed-meshheading:21550236-Fructose-Bisphosphatase,
pubmed-meshheading:21550236-Humans,
pubmed-meshheading:21550236-Inhibitory Concentration 50,
pubmed-meshheading:21550236-Liver,
pubmed-meshheading:21550236-Mice,
pubmed-meshheading:21550236-Molecular Structure
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
|
|
pubmed:affiliation |
F. Hoffmann-La Roche Ltd, Discovery Research Basel, CH-4070 Basel, Switzerland.
|
|
pubmed:publicationType |
Journal Article
|
