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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-7-25
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pubmed:abstractText |
The transcription factor PAX5 is essential for the activation of B-cell-specific genes and for the silencing of myeloid-specific genes. We previously determined the molecular mechanism by which PAX5 silences the myeloid-specific colony-stimulating-factor-receptor (Csf1R) gene and showed that PAX5 directly binds to the Csf1r promoter as well as to an intronic enhancer that generates an antisense transcript in B cells. Here we examine the role of PAX5 in the regulation of sense and antisense transcription in B cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/B-Cell-Specific Activator Protein,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/proto-oncogene protein Spi-1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-2399
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pubmed:author |
pubmed-author:BoniferConstanzeC,
pubmed-author:BouhlelM AmineMA,
pubmed-author:ClarkeDeborahD,
pubmed-author:IngramRichard MRM,
pubmed-author:KrügerImmeI,
pubmed-author:KuluDivineD,
pubmed-author:PhilipsenSjaakS,
pubmed-author:SuskeGuntramG,
pubmed-author:TagohHiromiH,
pubmed-author:ValeauxStephanieS,
pubmed-author:WilsonNicolaN
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pubmed:copyrightInfo |
Copyright © 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
730-40.e1-2
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pubmed:meshHeading |
pubmed-meshheading:21549805-Animals,
pubmed-meshheading:21549805-B-Cell-Specific Activator Protein,
pubmed-meshheading:21549805-B-Lymphocytes,
pubmed-meshheading:21549805-Base Sequence,
pubmed-meshheading:21549805-Binding Sites,
pubmed-meshheading:21549805-Cell Line,
pubmed-meshheading:21549805-Cell Line, Tumor,
pubmed-meshheading:21549805-Cells, Cultured,
pubmed-meshheading:21549805-Chromatin Immunoprecipitation,
pubmed-meshheading:21549805-DNA, Antisense,
pubmed-meshheading:21549805-Gene Expression Regulation,
pubmed-meshheading:21549805-Mice,
pubmed-meshheading:21549805-Mice, Knockout,
pubmed-meshheading:21549805-Mutation,
pubmed-meshheading:21549805-Promoter Regions, Genetic,
pubmed-meshheading:21549805-Protein Binding,
pubmed-meshheading:21549805-Proto-Oncogene Proteins,
pubmed-meshheading:21549805-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:21549805-Sp3 Transcription Factor,
pubmed-meshheading:21549805-Trans-Activators
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pubmed:year |
2011
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pubmed:articleTitle |
Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.
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pubmed:affiliation |
Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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