Linked Life Data

21546

Source:http://linkedlifedata.com/resource/pubmed/id/21546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1977-12-29
pubmed:abstractText
The histoincompatibility in the DK-OR-1 (B13B13) and DK/OR-3 (B19B19) inbred White Leghorn chicken lines was assessed with the Simonsen's spleen assay, GVHR mortality counts and antibody production by transferred cells in embryonic in vivo hosts. The two lines appear to be sufficiently histocompatible for use in cell transfer experiments. The occurrence of antigen responsive cells (ARC) and precursor cells in bone marrow as assessed with the in vivo culture and baby chick immune enhancement assays. Bone marrow of unimmunized donors possessed very little anti-MRBC immune responsiveness. Bone marrow cells from MRBC-primed donors, however, showed low anti-MRBC activity in the in vivo culture which could be elevated with a second antigen stimulation. Chicks grafted as embryos with bone marrow from immunized donors responded to MRBC immunization in an enhanced manner as compared to the control untreated chicks which responded poorly if at all to the antigen. Immunization appears (a) to increase the pool of potential ARC in the bone marrow of the donor and (b) to augment the responsiveness of bone marrow cells transferred into embryonic hosts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Cell transfer studies with the DK/or inbred chicken lines.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.