Linked Life Data

215466

Source:http://linkedlifedata.com/resource/pubmed/id/215466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1979-3-24
pubmed:abstractText
The specific inhibitor of thrombin-hirudin was used for studying the mechanism of activating effect of ACTH and adrenaline upon the unenzymatic fibrinolysis (UEF), the latter characterizing the function of the anticoagulating system (ACS). Simultaneous administration of ACTH and hirudin to animals subjected to the immobilization stress did not reduce the effect of ACTH upon UEF, while simultaneous administration of adrenaline and hirudin revealed a diminished effect of the former. This suggests different mechanisms of ACTH and adrenaline effects upon UEF: the stimulating effect of noradrenaline is realized through thrombinogenesis followed by activation of the ACS function and by an increase of UEF and therefore inhibitable by hirudin which form an inactive complex with thrombin. While the stimulating effect of ACTH upon UEF is exerted, apparently, not through thrombinogenesis and hence is valid even in presence of hirudin. Hirudin proper exerts no effect upon UEF.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0015-329X
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1567-74
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
[Effect of hirudin on hormonally caused activation of nonenzymatic fibrinolysis in immobilization stress].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract