Linked Life Data

21546252

Source:http://linkedlifedata.com/resource/pubmed/id/21546252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-7-5
pubmed:abstractText
The innate immune system senses and protects against invading microorganisms and endogenous danger signals by triggering inflammatory and antimicrobial responses. However, dysregulation of these pathways, which involve the transcription factors nuclear factor-?B (NF-?B) and interferon regulatory factor (IRF) 3, can lead to severe inflammatory diseases. Tax1-binding protein 1 (TAX1BP1) plays a key role in the negative regulation of NF-?B and IRF3 signaling by acting in concert with the ubiquitin-editing enzyme A20. In addition to regulating A20 function in anti-inflammatory and antiviral signaling pathways, TAX1BP1 also coordinates its antiapoptotic activities. Moreover, TAX1BP1 can also function as a transcriptional coactivator for nuclear receptors and viral transactivators. In this review, we discuss these findings in light of the emerging role of TAX1BP1 as a ubiquitin-binding adaptor protein.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0968-0004
pubmed:author
pubmed:copyrightInfo
2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-54
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond.
pubmed:affiliation
Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium; Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Technologiepark 927, B-9052 Ghent, Belgium.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't