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pubmed-article:2154620pubmed:abstractTextThe ability of B cells, B blasts, and macrophages to present Epstein-Barr virion antigens to autologous T cells and trigger their capacity to inhibit Epstein-Barr virus-induced B-cell transformation was tested. Macrophages were as efficient as B cells and B blasts in presenting the virus to T lymphocytes. This function required antigen processing, because it was inhibited by chloroquine treatment and by fixation of the antigen-presenting cells immediately after viral exposure but not 18 h later. T cells exposed to the purified Epstein-Barr virus envelope antigen gp350 coupled to immunostimulating complexes also showed inhibitory function. These results suggest that recognition of processed virion antigens elicits the generation of T-cell-mediated inhibition of Epstein-Barr virus-induced B-cell transformation.lld:pubmed
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pubmed-article:2154620pubmed:articleTitleEpstein-Barr virus (EBV) antigens processed and presented by B cells, B blasts, and macrophages trigger T-cell-mediated inhibition of EBV-induced B-cell transformation.lld:pubmed
pubmed-article:2154620pubmed:affiliationDepartment of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.lld:pubmed
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pubmed-article:2154620pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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