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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0004561,
umls-concept:C0014644,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024432,
umls-concept:C0368761,
umls-concept:C0449450,
umls-concept:C1444748,
umls-concept:C1510411,
umls-concept:C1522240
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pubmed:issue |
3
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pubmed:dateCreated |
1990-3-26
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pubmed:abstractText |
The ability of B cells, B blasts, and macrophages to present Epstein-Barr virion antigens to autologous T cells and trigger their capacity to inhibit Epstein-Barr virus-induced B-cell transformation was tested. Macrophages were as efficient as B cells and B blasts in presenting the virus to T lymphocytes. This function required antigen processing, because it was inhibited by chloroquine treatment and by fixation of the antigen-presenting cells immediately after viral exposure but not 18 h later. T cells exposed to the purified Epstein-Barr virus envelope antigen gp350 coupled to immunostimulating complexes also showed inhibitory function. These results suggest that recognition of processed virion antigens elicits the generation of T-cell-mediated inhibition of Epstein-Barr virus-induced B-cell transformation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2411422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2431484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2461518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2492575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2536092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2536113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2546674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2830541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2832478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2836501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2838046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2839689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2841417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2843474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2847872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2904885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2978457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2981780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-2981781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-3030940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-3033269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-3037547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-3156185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-3485173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6152688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6169663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6193218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6248876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6254073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6272965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6283120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6290853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6301696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6316160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6601277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-6709052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-7024458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2154620-7086144
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1398-401
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2154620-Antigens, Viral,
pubmed-meshheading:2154620-B-Lymphocytes,
pubmed-meshheading:2154620-Cells, Cultured,
pubmed-meshheading:2154620-Herpesvirus 4, Human,
pubmed-meshheading:2154620-Humans,
pubmed-meshheading:2154620-Lymphocyte Activation,
pubmed-meshheading:2154620-Macrophages,
pubmed-meshheading:2154620-T-Lymphocytes,
pubmed-meshheading:2154620-Virion
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pubmed:year |
1990
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pubmed:articleTitle |
Epstein-Barr virus (EBV) antigens processed and presented by B cells, B blasts, and macrophages trigger T-cell-mediated inhibition of EBV-induced B-cell transformation.
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pubmed:affiliation |
Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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