Linked Life Data

21543417

Source:http://linkedlifedata.com/resource/pubmed/id/21543417

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-8-5
pubmed:abstractText
Previous studies suggest ?-epithelial Na(+) channel protein (?-ENaC) may mediate myogenic constriction, a mechanism of blood flow autoregulation. A recent study demonstrated that mice with reduced levels of ?-ENaC (?-ENaC m/m) have delayed correction of whole kidney blood flow responses, suggesting defective myogenic autoregulatory capacity. Reduced renal autoregulatory capacity is linked to renal inflammation, injury, and hypertension. However, it is unknown whether ?-ENaC m/m mice have any complications associated with reductions in autoregulatory capacity such as renal inflammation, injury, or hypertension. To determine whether the previously observed altered autoregulatory control was associated with indicators of renal injury, we evaluated ?-ENaC m/m mice for signs of renal inflammation and tissue remodeling using marker expression. We found that inflammatory and remodeling markers, such as IL-1?, IL-6, TNF-?, collagen III and transforming growth factor-?, were significantly upregulated in ?-ENaC m/m mice. To determine whether renal changes were associated with changes in long-term control of blood pressure, we used radiotelemetry and found that 5-day mean arterial blood pressure (MAP) was significantly elevated in ?-ENaC m/m (120 ± 3 vs. 105 ± 2 mmHg, P = 0.016). Our findings suggest loss of ?-ENaC is associated with early signs of renal injury and increased MAP.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1522-1466
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
301
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F443-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Renal inflammation and elevated blood pressure in a mouse model of reduced {beta}-ENaC.
pubmed:affiliation
Dept. of Physiology and Biophysics, Univ. of Mississippi Medical Center, Jackson, 39216-4505, USA. hdrummond@umc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural