Linked Life Data

21541881

Source:http://linkedlifedata.com/resource/pubmed/id/21541881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2011-5-4
pubmed:abstractText
Fine- and coarse-sized titanium dioxide (TiO?) particles are considered to be relatively inert when inhaled. The goal of this study was to assess potential lung toxicity associated with well-characterized, non-dispersed rutile TiO? nanorods (10 × 40 nm). In vitro bioreactivity of TiO? nanorods was determined by electron spin resonance (ESR) to measure free radical production. To assess pulmonary effects in vivo, Sprague-Dawley rats were intratracheally instilled with saline, silica, or TiO? nanorods (10 ?g, 100 ?g, or 1 mg/rat). On d 1, 3, and 6 posttreatment, left lungs were preserved for microscopy and histopathology, and lung lavage was performed on right lungs. Additional rats were treated with saline or TiO? nanorods (100 ?g or 1 mg/rat) on d 0, intratracheally inoculated with 5 × 10(5) Listeria monocytogenes on d 3, and bacterial clearance was assessed. ESR showed a significant concentration-dependent generation of hydroxyl radicals by TiO? nanorods in the presence and absence of macrophages; however, the hydroxyl radical signals from TiO? samples were low compared to silica. Rats exposed to 1 mg of TiO? nanorods had significantly elevated levels of lung injury, inflammation, and lavage fluid monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-2 on d 1 and 3 that subsided by d 6, unlike the silica response that persisted. Immune cytokine secretion in the lung and bacterial clearance were not affected by preexposure to TiO? nanorods. To summarize, non-dispersed TiO? nanorods were found to induce radical formation and cellular oxidant production, and to generate transient and reversible pneumotoxic effects, and to not markedly alter pulmonary immune function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1528-7394
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
790-810
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods.
pubmed:affiliation
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. jur6@cdc.gov
pubmed:publicationType
Journal Article, Comparative Study