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pubmed:abstractText |
The sigma-1 receptor (?R1), a ligand-operated chaperone, has been inferred to be neuroprotective in previous studies using ?R1 ligands. The ?R1 specificity of the protective function, however, has yet to be firmly established, due to the existence of non-?R1 targets of the ligands. Here, we used the ?R1-knockout mouse (Sigmar1(-/-)) to demonstrate unambiguously the role of the ?R1 in protecting the retinal ganglion cells against degeneration after acute damage to the optic nerve.
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