Linked Life Data

2153765

Source:http://linkedlifedata.com/resource/pubmed/id/2153765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-3-5
pubmed:abstractText
The present randomized, prospective study was designed to assess whether alternating induction cyclophosphamide, doxorubicin, vincristine-altretamine (hexamethylmelamine), etoposide, and methotrexate (CAV-HEM) chemotherapy is better than standard chemotherapy (CAV) in improving response, survival, and remission time in 577 evaluable patients having extensive-disease small-cell lung cancer (SCLC). In addition, the study was designed to assess the impact of maintenance chemotherapy following a complete response (CR) on the time to progression and survival. The response rates (CR plus partial response [PR]) for CAV-HEM and CAV were 64% and 61%, respectively, but 23% of the patients on CAV-HEM achieved a CR compared with 16% for CAV alone (P = .03). Among complete responders, the continuation of therapy significantly increased the remission time for patients on CAV, while maintenance therapy for patients on CAV-HEM had no significant impact on remission time. However, the increased remission had little effect on survival. Patients on CAV maintenance therapy survived marginally longer than those patients on no maintenance therapy, whereas patients who received CAV-HEM and no maintenance therapy survived longer than those on maintenance therapy. CAV-HEM was associated with significantly higher severity of complications (ie, mainly myelosuppression) than CAV (P = .01). Maintenance chemotherapy was associated with significantly more complications than no maintenance therapy. Patients on CAV-HEM lived significantly longer than those on CAV alone (45.9 weeks v 42.7 weeks; P = .002). Ten percent of patients treated on CAV-HEM survived at least 2 years, compared with 4% on CAV alone. In our study involving patients with extensive-disease SCLC, the alternating induction chemotherapy significantly increased the CR rates and had a small impact on long-term survival compared with the results achieved with standard induction chemotherapy. Moreover, when the alternating induction chemotherapy was used, long-term maintenance chemotherapy was not needed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0732-183X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
230-40
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:2153765-Aged, pubmed-meshheading:2153765-Altretamine, pubmed-meshheading:2153765-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:2153765-Carcinoma, Small Cell, pubmed-meshheading:2153765-Cyclophosphamide, pubmed-meshheading:2153765-Doxorubicin, pubmed-meshheading:2153765-Etoposide, pubmed-meshheading:2153765-Female, pubmed-meshheading:2153765-Follow-Up Studies, pubmed-meshheading:2153765-Humans, pubmed-meshheading:2153765-Lung Neoplasms, pubmed-meshheading:2153765-Male, pubmed-meshheading:2153765-Methotrexate, pubmed-meshheading:2153765-Middle Aged, pubmed-meshheading:2153765-Multicenter Studies as Topic, pubmed-meshheading:2153765-Prospective Studies, pubmed-meshheading:2153765-Random Allocation, pubmed-meshheading:2153765-Remission Induction, pubmed-meshheading:2153765-Survival Rate, pubmed-meshheading:2153765-Vincristine
pubmed:year
1990
pubmed:articleTitle
A randomized comparison of standard chemotherapy versus alternating chemotherapy and maintenance versus no maintenance therapy for extensive-stage small-cell lung cancer: a phase III study of the Eastern Cooperative Oncology Group.
pubmed:affiliation
Johns Hopkins Oncology Center, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Multicenter Study