| pubmed-article:21536859 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0599295 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0023448 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C1961102 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C0180683 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C1551083 | lld:lifeskim |
| pubmed-article:21536859 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:21536859 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:21536859 | pubmed:dateCreated | 2011-7-1 | lld:pubmed |
| pubmed-article:21536859 | pubmed:abstractText | The Ets-related gene (ERG) is an Ets-transcription factor required for normal blood stem cell development. ERG expression is down-regulated during early T-lymphopoiesis but maintained in T-acute lymphoblastic leukemia (T-ALL), where it is recognized as an independent risk factor for adverse outcome. However, it is unclear whether ERG is directly involved in the pathogenesis of T-ALL and how its expression is regulated. Here we demonstrate that transgenic expression of ERG causes T-ALL in mice and that its knockdown reduces the proliferation of human MOLT4 T-ALL cells. We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer. This enhancer is not active in normal T cells but in transgenic mice targets expression to fetal liver c-kit(+) cells, adult bone marrow stem/progenitors and early CD4(-)CD8(-) double-negative thymic progenitors. Taken together, these data illustrate that ERG promotes T-ALL and that failure to extinguish activity of stem cell enhancers associated with regulatory transcription factors such as ERG can contribute to the development of leukemia. | lld:pubmed |
| pubmed-article:21536859 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21536859 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21536859 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21536859 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21536859 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:WongJason WJW | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:MacKenzieKare... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:GöttgensBerth... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:GronerYoramY | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:IzraeliShaiS | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:BirgerYehudit... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:PimandaJohn... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:KnezevicKathy... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:SpensbergerDo... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:LockRichardR | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:Chandrakantha... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:ThomsJulie... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:OramS HelenSH | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:FosterSamS | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:KinstonSarah... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:KirschenbaumY... | lld:pubmed |
| pubmed-article:21536859 | pubmed:author | pubmed-author:JonquieresGeo... | lld:pubmed |
| pubmed-article:21536859 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21536859 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:21536859 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:21536859 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21536859 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21536859 | pubmed:pagination | 7079-89 | lld:pubmed |
| pubmed-article:21536859 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21536859 | pubmed:meshHeading | pubmed-meshheading:21536859... | lld:pubmed |
| pubmed-article:21536859 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21536859 | pubmed:articleTitle | ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. | lld:pubmed |
| pubmed-article:21536859 | pubmed:affiliation | Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia. | lld:pubmed |
| pubmed-article:21536859 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21536859 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2078 | entrezgene:pubmed | pubmed-article:21536859 | lld:entrezgene |
| entrez-gene:13876 | entrezgene:pubmed | pubmed-article:21536859 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21536859 | lld:entrezgene |
