Linked Life Data

21536374

Source:http://linkedlifedata.com/resource/pubmed/id/21536374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-5-31
pubmed:abstractText
Overexpression of Id family proteins inhibits cell differentiation and enhances cell proliferation and invasiveness. Although Id1 is the Id family member mostly linked to tumorigenesis, its role in lung cancer is unclear. An elevated Id1 expression was observed in lung cancer cell lines as well as lung cancer tissues. Id1 overexpression increased cell proliferation while Id1 knockdown decreased cell proliferation, mostly through Akt-related pathway. Nude mice study further confirmed an increased tumor growth in Id1-overexpressing cells and a decreased tumor growth in Id1-knockdowned cells. In conclusion, inactivation of Id1 may provide a novel strategy for treatment of lung cancer patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1872-7980
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
307
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway.
pubmed:affiliation
Division of Thoracic Surgery, Department of Surgery, E-DA Hospital, No. 1 E-DA Road, Jiau-Shu, Kaohsiung 824, Taiwan, ROC.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't