Linked Life Data

21535264

Source:http://linkedlifedata.com/resource/pubmed/id/21535264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-5-3
pubmed:abstractText
Hypoxia-inducible factor 1? (HIF-1?) is a pivotal regulator of hypoxic and ischaemic vascular responses that drives transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis and arteriogenesis. Previous reports based on gene knockout technology have demonstrated that HIF-1? can promote osteogenesis. However, this protein is easily degraded in a normoxic state, which makes in vitro studies of HIF-1?-induced mesenchymal stem cell (MSC) osteogenesis difficult. For better understanding of HIF-1? promoting osteogenesis, the role of HIF-1?-induced MSC osteogenesis in the normoxic state has been investigated here.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1365-2184
pubmed:author
pubmed:copyrightInfo
© 2011 Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
234-43
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
In vitro study of enhanced osteogenesis induced by HIF-1?-transduced bone marrow stem cells.
pubmed:affiliation
School of Stomatology, Tongji University, Shanghai, China.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't