|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0014939,
umls-concept:C0017262,
umls-concept:C0034804,
umls-concept:C0035696,
umls-concept:C0039286,
umls-concept:C0080103,
umls-concept:C0086418,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0441889,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1366563,
umls-concept:C1704632,
umls-concept:C1705334,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1990-3-7
|
|
pubmed:abstractText |
The pNR-2 mRNA is regulated by oestrogens in cell lines established from metastatic human breast cancer cells. The levels of the pNR-2 and oestrogen receptor RNAs have been measured in 96 tumour samples from patients undergoing surgery for breast cancer. Oestrogen receptor mRNA was detected in 90% of the 60 primary breast tumour samples from patients not receiving endocrine therapy at the time of surgery, whereas the pNR-2 RNA was detected in 57%. In primary tumours the expression of pNR-2 was entirely dependent upon oestrogen receptor RNA expression. When the 60 primary tumours were considered, pNR-2 and oestrogen receptor mRNA levels were significantly correlated. There was no significant correlation for pNR-2 positive tumours. pNR-2 mRNA levels were similar in tumours of pre- and post-menopausal patients and were independent of tumour differentiation and nodal status. Oestrogen receptor and pNR-2 mRNA levels were also measured in 21 tumour samples from patients receiving primary tamoxifen therapy. Eleven of these had shown an objective response and a significantly larger number of tumours from these patients contained pNR-2 mRNA than from patients who did not respond (chi 2 = 6.08, P less than 0.025).
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-13499785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-170527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-2430688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-2458337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-2468045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-2824472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-2851309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-2893663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-3041593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-3191480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-3321071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-3588310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-3665845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-3865204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-4357757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-6256054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-6324130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-6329918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-6722808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-688225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-6897676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2153395-7448733
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Breast Cancer,
http://linkedlifedata.com/resource/pubmed/keyword/Cancer,
http://linkedlifedata.com/resource/pubmed/keyword/Data Analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Histology,
http://linkedlifedata.com/resource/pubmed/keyword/Hormone Receptors--analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Measurement,
http://linkedlifedata.com/resource/pubmed/keyword/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/keyword/Menopause,
http://linkedlifedata.com/resource/pubmed/keyword/Neoplasms,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Tamoxifen--therapeutic use
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0007-0920
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
32-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2153395-Humans,
pubmed-meshheading:2153395-Estrogens,
pubmed-meshheading:2153395-Breast Neoplasms,
pubmed-meshheading:2153395-Female,
pubmed-meshheading:2153395-Lymphatic Metastasis,
pubmed-meshheading:2153395-RNA, Messenger,
pubmed-meshheading:2153395-RNA, Neoplasm,
pubmed-meshheading:2153395-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:2153395-Tamoxifen
|
