|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2011-5-2
|
|
pubmed:abstractText |
The serine protease inhibitors (serpins) are anti-inflammatory proteins that have various functions. By screening a diverse panel of viruses, we demonstrate that the serpin antithrombin III (ATIII) has a broad-spectrum anti-viral activity for HIV-1, HCV and HSV. To investigate the mechanism of action in more detail we investigated the HIV-1 inhibition. Using gene-expression arrays we found that multiple host cell signal transduction pathways were activated by ATIII in HIV-1 infected cells but not in uninfected controls. Moreover, the signal pathways initiated by ATIII treatment, were more than 200-fold increased by the use of heparin-activated ATIII. The most up-regulated transcript in HIV-1 infected cells was prostaglandin synthetase-2 (PTGS2). Furthermore, we found that over-expression of PTGS2 reduced levels of HIV-1 replication in human PBMC. These findings suggest a central role for serpins in the host innate anti-viral response. Host factors such as PTGS2 elicited by ATIII treatment could be exploited in the development of novel anti-viral interventions.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-10898721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-11116082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-11149899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-11483776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-11771733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-12192009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-12411597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-12617738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-1332592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-1433527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-14705960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-15720983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-15766575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-16012749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-16095456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-16875754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-17023547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-17555371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-17654345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-17885308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-18539447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-18707157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-18852471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-19226329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-20463814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-4332040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-4340949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-7615818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-8508691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-8691079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-8723455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-9039946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-9242546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533265-9337204
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
6
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e18589
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication.
|
|
pubmed:affiliation |
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
