Linked Life Data

21532169

Source:http://linkedlifedata.com/resource/pubmed/id/21532169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-5-2
pubmed:abstractText
Surface expression levels of high-affinity immunoglobulin E (IgE) receptors (Fc?RI) on mast cells are regulated by constitutive internalization from the plasma membrane, which is thought to be an important determinant of Fc?RI-mediated signaling potential. However, molecular mechanism of Fc?RI trafficking has remained poorly understood. Rab proteins are small guanosine 5'-triphosphatases (GTPases) involved in the regulation of membrane traffic. In particular, Rab5 has been shown to regulate transport in the early endocytic pathway, whereas it is not known whether the Fc?RI surface expression levels are regulated by Rab5. In this study, we investigated the role of individual Rab5 isoforms in mast cells by small interfering RNA knockdown method. Our results demonstrate that Rab5a knockdown enhanced Fc?RI-dependent mast cell activation and upregulated Fc?RI surface expression in its steady state. In contrast, Rab5c knockdown caused suppression of the activation. These findings revealed modulatory and individual roles of Rab5 isoforms in mast cell functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1347-5215
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-3
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Rab5a regulates surface expression of Fc?RI and functional activation in mast cells.
pubmed:affiliation
Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan. natsukokageyama-tky@umin.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't