Source:http://linkedlifedata.com/resource/pubmed/id/21531981
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
25
|
| pubmed:dateCreated |
2011-6-24
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| pubmed:abstractText |
?-glucans have been reported to function as a potent adjuvant to stimulate innate and adaptive immune responses. However, ?-glucans from different sources are differential in their structure, conformation, and thus biologic activity. Different preparations of ?-glucans, soluble versus particulate, further complicate their mechanism of action. Here we show that yeast-derived particulate ?-glucan activated dendritic cells (DCs) and macrophages via a C-type lectin receptor dectin-1 pathway. Activated DCs by particulate ?-glucan promoted Th1 and cytotoxic T-lymphocyte priming and differentiation in vitro. Treatment of orally administered yeast-derived particulate ?-glucan elicited potent antitumor immune responses and drastically down-regulated immunosuppressive cells, leading to the delayed tumor progression. Deficiency of the dectin-1 receptor completely abrogated particulate ?-glucan-mediated antitumor effects. In contrast, yeast-derived soluble ?-glucan bound to DCs and macrophages independent of the dectin-1 receptor and did not activate DCs. Soluble ?-glucan alone had no therapeutic effect but significantly augmented antitumor monoclonal antibody-mediated therapeutic efficacy via a complement activation pathway but independent of dectin-1 receptor. These findings reveal the importance of different preparations of ?-glucans in the adjuvant therapy and allow for the rational design of immunotherapeutic protocols usable in clinical trials.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Glucans,
http://linkedlifedata.com/resource/pubmed/chemical/dectin 1
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1528-0020
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| pubmed:author |
pubmed-author:CaiYihuaY,
pubmed-author:DingChuanlinC,
pubmed-author:GunnLaceyL,
pubmed-author:IwakuraYoichiroY,
pubmed-author:KloeckerGoetzG,
pubmed-author:KuoZ FZF,
pubmed-author:LiBingB,
pubmed-author:QiChunjianC,
pubmed-author:QianKeqingK,
pubmed-author:SaijoShinobuS,
pubmed-author:VasilakosJohnJ,
pubmed-author:YannelliJohn RJR
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| pubmed:issnType |
Electronic
|
| pubmed:day |
23
|
| pubmed:volume |
117
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6825-36
|
| pubmed:meshHeading |
pubmed-meshheading:21531981-Adaptive Immunity,
pubmed-meshheading:21531981-Adjuvants, Immunologic,
pubmed-meshheading:21531981-Animals,
pubmed-meshheading:21531981-Cell Line, Tumor,
pubmed-meshheading:21531981-Cells, Cultured,
pubmed-meshheading:21531981-Dendritic Cells,
pubmed-meshheading:21531981-Humans,
pubmed-meshheading:21531981-Immunity, Innate,
pubmed-meshheading:21531981-Macrophages,
pubmed-meshheading:21531981-Membrane Proteins,
pubmed-meshheading:21531981-Mice,
pubmed-meshheading:21531981-Mice, Inbred C57BL,
pubmed-meshheading:21531981-Neoplasms,
pubmed-meshheading:21531981-Nerve Tissue Proteins,
pubmed-meshheading:21531981-Phagocytosis,
pubmed-meshheading:21531981-Saccharomyces cerevisiae,
pubmed-meshheading:21531981-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:21531981-Th1 Cells,
pubmed-meshheading:21531981-beta-Glucans
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived ?-glucans.
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| pubmed:affiliation |
Division of Hematology/Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|