Linked Life Data

2153179

Source:http://linkedlifedata.com/resource/pubmed/id/2153179

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-9
pubmed:abstractText
Lattices made of collagen and fibroblasts can be used as dermal equivalents to grow human keratinocytes in vitro. When these cultures are performed in a medium containing delipidized serum, the lattice is eventually degraded by the growing epithelium. The digestion of the dermal equivalent is due to the secretion of a collagenase by the keratinocytes. This degradation does not occur in cultures containing total serum or supplemented with retinoic acid. We show in this paper that retinoic acid inhibits the secretion of this keratinocyte collagenase in a dose-dependent manner. In the light of this result, the possible involvement of collagenase inhibition in the therapeutic effect of retinoic acid in skin disorders and skin aging must be considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-51
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Retinoic acid inhibits the production of collagenase by human epidermal keratinocytes.
pubmed:affiliation
Cell Biology Department, Centre International de Recherches Dermatologiques (CIRD), Sophia Antipolis, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't