|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2011-5-2
|
|
pubmed:abstractText |
Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SHTAP protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1932-7420
|
|
pubmed:author |
pubmed-author:Asin-CayuelaJorgeJ,
pubmed-author:CámaraYolandaY,
pubmed-author:Erdjument-BromageHediyeH,
pubmed-author:FranzThomasT,
pubmed-author:GustafssonClaes MCM,
pubmed-author:HabermannBiancaB,
pubmed-author:HallbergB MartinBM,
pubmed-author:HultenbyKjellK,
pubmed-author:KukatChristianC,
pubmed-author:LarssonNils-GöranNG,
pubmed-author:ParkChan BaeCB,
pubmed-author:RuzzenenteBenedettaB,
pubmed-author:SIMR PRP,
pubmed-author:ShiYonghongY,
pubmed-author:TempstPaulP,
pubmed-author:WibomRolfR
|
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
4
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
527-39
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:21531335-Animals,
pubmed-meshheading:21531335-Blotting, Northern,
pubmed-meshheading:21531335-Cardiomyopathies,
pubmed-meshheading:21531335-Carrier Proteins,
pubmed-meshheading:21531335-DNA, Mitochondrial,
pubmed-meshheading:21531335-Gene Expression Regulation, Developmental,
pubmed-meshheading:21531335-Immunoprecipitation,
pubmed-meshheading:21531335-Integrases,
pubmed-meshheading:21531335-Methyltransferases,
pubmed-meshheading:21531335-Mice,
pubmed-meshheading:21531335-Mice, Knockout,
pubmed-meshheading:21531335-Mitochondria,
pubmed-meshheading:21531335-Mitochondrial Diseases,
pubmed-meshheading:21531335-Oxidative Phosphorylation,
pubmed-meshheading:21531335-Protein Biosynthesis,
pubmed-meshheading:21531335-Protein Methyltransferases,
pubmed-meshheading:21531335-RNA, Ribosomal,
pubmed-meshheading:21531335-Ribosomal Proteins,
pubmed-meshheading:21531335-Ribosomes,
pubmed-meshheading:21531335-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:21531335-Transcription, Genetic,
pubmed-meshheading:21531335-Transcription Factors
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
|
|
pubmed:affiliation |
Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
