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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0061666,
umls-concept:C0162326,
umls-concept:C0185117,
umls-concept:C0205147,
umls-concept:C0206679,
umls-concept:C1413745,
umls-concept:C1423085,
umls-concept:C1546857,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
1990-1-22
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pubmed:abstractText |
The role of the 5' noncoding region of the herpes simplex virus type 1 glycoprotein C (gC) gene in viral gene expression was investigated with recombinant herpesviruses that contained the bacterial beta-galactosidase gene under the control of the gC promoter-regulatory region. Each of these viruses had the same DNA sequences from the start of gC transcription upstream to -114 but had variable segments of the downstream 140-base-pair sequence that is between the start of gC transcription and translation. Analysis of beta-galactosidase expression and mRNA synthesis from these viruses demonstrated the importance of DNA sequences from the start of gC transcription downstream to +38 for optimal expression from the gC promoter.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-2821283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-2832940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-2833425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-2848220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-2985955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3004024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3018926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3025606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3031620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3037112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3323813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-3943125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-6300426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2152831-6325883
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
445-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2152831-Animals,
pubmed-meshheading:2152831-Base Sequence,
pubmed-meshheading:2152831-Cell Transformation, Viral,
pubmed-meshheading:2152831-Gene Expression Regulation, Viral,
pubmed-meshheading:2152831-Genes, Bacterial,
pubmed-meshheading:2152831-Genes, Viral,
pubmed-meshheading:2152831-Molecular Sequence Data,
pubmed-meshheading:2152831-Promoter Regions, Genetic,
pubmed-meshheading:2152831-RNA, Messenger,
pubmed-meshheading:2152831-Recombination, Genetic,
pubmed-meshheading:2152831-Simplexvirus,
pubmed-meshheading:2152831-Transcription, Genetic,
pubmed-meshheading:2152831-Vero Cells,
pubmed-meshheading:2152831-Viral Envelope Proteins,
pubmed-meshheading:2152831-Viral Structural Proteins,
pubmed-meshheading:2152831-beta-Galactosidase
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pubmed:year |
1990
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pubmed:articleTitle |
Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene.
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pubmed:affiliation |
Department of Microbiology, University of Tennessee, Knoxville 37996-0845.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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