Linked Life Data

2152716

Source:http://linkedlifedata.com/resource/pubmed/id/2152716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-7-29
pubmed:abstractText
The efficacy and safety of oral prazosin was assessed in 108 ambulatory mild (91-104 mmHg diastolic pressure) to moderate (104-114 mmHg) essential hypertensive patients. After a 2 week no-drug control period, prazosin, 2, 4, 8 or 10 mg per day was given in 2 weeks periods as needed to obtain control of blood pressure. A seating diastolic pressure of < or = 90 mmHg was defined as adequate response. Satisfactory blood pressure response was obtained in 86% of patients, with doses of 4 mg or less in 70%. Treatment results were not related to initial blood pressure level, but obese patients were more resistant to drug effect (p < 0.05). Heart rate and laboratory parameters did not change. Adverse effects, mainly headache, dizziness and palpitations, were noticed in 46 patients (43%) and occurred with the lower dose in 78% of them. Adverse effects were slight or moderated and lasted from 1 day to 2 weeks in most patients. Treatment was discontinued in 2 patients, one because of persistent dizziness which was promptly relieved after stopping the drug and another due to syncope occurring immediately after a dose increase. We conclude that oral prazosin at low doses is an effective and well-tolerated drug which should be considered in the treatment of mild to moderate hypertension.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0034-9887
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
164-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[The antihypertensive response to prazosin, a selective vascular alpha blocker. A multicenter study].
pubmed:affiliation
Centro Cardiovascular, Hospital Clínico, Universidad de Chile, Santiago.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Research Support, Non-U.S. Gov't, Multicenter Study