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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-4-28
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pubmed:abstractText |
Several pathways contribute to mechanisms by which ethanol induces oxidant stress. While some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not. There is a need to develop oral models of significant ethanol-induced liver injury and to evaluate the possible role of CYP2E1 in ethanol actions in such models.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9875
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
802-11
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pubmed:dateRevised |
2011-11-9
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pubmed:meshHeading |
pubmed-meshheading:21525766-Animals,
pubmed-meshheading:21525766-Biocatalysis,
pubmed-meshheading:21525766-Chlormethiazole,
pubmed-meshheading:21525766-Cytochrome P-450 CYP2E1,
pubmed-meshheading:21525766-Enzyme Activation,
pubmed-meshheading:21525766-Enzyme Inhibitors,
pubmed-meshheading:21525766-Ethanol,
pubmed-meshheading:21525766-Fatty Liver,
pubmed-meshheading:21525766-Humans,
pubmed-meshheading:21525766-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:21525766-Liver,
pubmed-meshheading:21525766-Mice,
pubmed-meshheading:21525766-Mice, Knockout,
pubmed-meshheading:21525766-Oxidative Stress
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pubmed:year |
2010
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pubmed:articleTitle |
Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity.
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pubmed:affiliation |
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, N.Y., USA. arthur.cederbaum@mssm.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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