Source:http://linkedlifedata.com/resource/pubmed/id/21525392
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2011-5-20
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| pubmed:abstractText |
The peripheral B cell compartment in mice and humans is maintained by continuous production of transitional B cells in the bone marrow. In other species, however, including rabbits, B lymphopoiesis in the bone marrow abates early in life, and it is unclear how the peripheral B cell compartment is maintained. We identified transitional B cells in rabbits and classified them into T1 (CD24(high)CD21(low)) and T2 (CD24(high)CD21(+)) B cell subsets. By neutralizing B cell-activating factor in vivo, we found an arrest in peripheral B cell development at the T1 B cell stage. Surprisingly, T1 B cells were present in GALT, blood, and spleen of adult rabbits, long after B lymphopoiesis was arrested. T1 B cells were distinct from their counterparts in other species because they are proliferating and the Ig genes are somatically diversified. We designate these newly described cells as T1d B cells and propose a model in which they develop in GALT, self renew, continuously differentiate into mature B cells, and thereby maintain peripheral B cell homeostasis in adults in the absence of B lymphopoiesis.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
186
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6437-44
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| pubmed:dateRevised |
2011-9-26
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| pubmed:meshHeading |
pubmed-meshheading:21525392-Animals,
pubmed-meshheading:21525392-Antigens, CD24,
pubmed-meshheading:21525392-B-Cell Activating Factor,
pubmed-meshheading:21525392-B-Lymphocyte Subsets,
pubmed-meshheading:21525392-B-Lymphocytes,
pubmed-meshheading:21525392-Base Sequence,
pubmed-meshheading:21525392-Cell Differentiation,
pubmed-meshheading:21525392-Cell Proliferation,
pubmed-meshheading:21525392-Flow Cytometry,
pubmed-meshheading:21525392-Gastrointestinal Tract,
pubmed-meshheading:21525392-Homeostasis,
pubmed-meshheading:21525392-Humans,
pubmed-meshheading:21525392-Lymphoid Tissue,
pubmed-meshheading:21525392-Mice,
pubmed-meshheading:21525392-Molecular Sequence Data,
pubmed-meshheading:21525392-Precursor Cells, B-Lymphoid,
pubmed-meshheading:21525392-Rabbits,
pubmed-meshheading:21525392-Receptors, Complement 3d,
pubmed-meshheading:21525392-Sequence Homology, Nucleic Acid,
pubmed-meshheading:21525392-Time Factors
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Somatically diversified and proliferating transitional B cells: implications for peripheral B cell homeostasis.
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| pubmed:affiliation |
Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|