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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-4-27
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pubmed:abstractText |
Gelatin-based microcapsule production using a microfluidic system and the feasibility of the resultant microcapsules for constructing spherical tissues surrounded by heterogeneous cells were studied. The first cell-encapsulation and subsequent cell-enclosing microparticle encapsulation were achieved using a microfluidic flow-focusing droplet production system. A hollow-core structure of about 150 ?m in diameter was developed by incubating the resultant microparticles at 37 °C, which induced thermal melting of the enclosed unmodified gelatin microparticles. Mammalian cells filled the hollow-cores after 4 days of incubation. A cell layer on the cell-enclosing microcapsules was developed by simply suspending the microcapsules in medium containing adherent fibroblast cells. This method may prove useful for the generation of gelatin microcapsules using a microfluidic system for formation of artificial tissue constructs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-12566253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-15052636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-16080713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-17518648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-17655488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-17705234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-18316742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-18458450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-18566957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-18584086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-19345991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-19656563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-20144915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21522492-2730666
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pubmed:language |
eng
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pubmed:journal |
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pubmed:status |
PubMed-not-MEDLINE
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pubmed:issn |
1932-1058
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13402
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pubmed:dateRevised |
2011-7-28
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pubmed:year |
2011
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pubmed:articleTitle |
Cell-enclosing gelatin-based microcapsule production for tissue engineering using a microfluidic flow-focusing system.
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pubmed:publicationType |
Journal Article
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