Source:http://linkedlifedata.com/resource/pubmed/id/21521383
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2011-6-14
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| pubmed:abstractText |
Ischemia time is a prognostic factor in renal transplantation for postoperative graft function and survival. Kidney transplants from living donors have a higher survival rate than deceased donor kidneys probably because of shorter ischemia time. We hypothesized that measurement of intraoperative kidney oxygenation (?HbO(2) ) and microvascular perfusion predicts postoperative graft function. We measured microvascular hemoglobin oxygen saturation by reflectance spectrophotometry and microcirculatory kidney perfusion by laser Doppler flowmetry 5 and 30min after kidney reperfusion on the organ surface in 53 renal transplant patients including 19 grafts from living donors. These values were related to systemic hemodynamics, cold ischemia time (cit), early postoperative graft function and length of hospital stay. ?HbO(2) improved 30 min after reperfusion compared to 5 min (from 67% to 71%, P <?0.05). ?HbO(2) correlated with mean arterial blood pressure and central venous pH (P < 0.01). Most importantly, ?HbO(2) was significantly higher in kidneys from living compared with deceased donors (74% vs. 63%) and in kidneys without vs. with biopsy-proven postoperative rejection (71% vs. 45%, P <?0.001). Finally, ?HbO(2) correlated positively with cit and postoperative creatinine clearance and negatively with postoperative plasma creatinine, need for hemodialysis and length of hospital stay. Our results suggest higher oxygen extraction and thus oxygen demand of the grafts shortly after reperfusion. The intraoperative measurement of tissue oxygenation in kidney transplants is predictive of early postoperative graft function. Future studies should evaluate the potential effect of intraoperative therapeutic maneuvers to improve organ tissue oxygenation in renal transplantation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1432-2277
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
24
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
687-96
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| pubmed:meshHeading |
pubmed-meshheading:21521383-Adult,
pubmed-meshheading:21521383-Cold Ischemia,
pubmed-meshheading:21521383-Female,
pubmed-meshheading:21521383-Graft Survival,
pubmed-meshheading:21521383-Humans,
pubmed-meshheading:21521383-Kidney,
pubmed-meshheading:21521383-Kidney Transplantation,
pubmed-meshheading:21521383-Male,
pubmed-meshheading:21521383-Microcirculation,
pubmed-meshheading:21521383-Middle Aged,
pubmed-meshheading:21521383-Oxygen,
pubmed-meshheading:21521383-Regional Blood Flow,
pubmed-meshheading:21521383-Reperfusion Injury,
pubmed-meshheading:21521383-Tissue and Organ Procurement,
pubmed-meshheading:21521383-Warm Ischemia
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| pubmed:year |
2011
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| pubmed:articleTitle |
Prognostic value of intraoperative renal tissue oxygenation measurement on early renal transplant function.
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| pubmed:affiliation |
Department of Anesthesiology & Intensive Care, University Hospital Rostock, Germany. t.w.l.scheeren@anest.umcg.nl
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| pubmed:publicationType |
Journal Article
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