|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0005885,
umls-concept:C0020663,
umls-concept:C0032005,
umls-concept:C0085355,
umls-concept:C0242485,
umls-concept:C0521428,
umls-concept:C0597719,
umls-concept:C1367469,
umls-concept:C1522496,
umls-concept:C1882417
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2011-5-6
|
|
pubmed:abstractText |
The relationship between hypothalamus/pituitary/adrenal (HPA) axis functioning and (visceral) obesity may be explained by single-nucleotide polymorphisms (SNPs) of the HPA axis. Objective? To investigate the relationship between the HPA axis SNP's 'BclI' in the glucocorticoid receptor gene and C8246T in the POMC gene and anthropometric measurements, body composition, 5-h cortisol concentrations, HPA axis feedback sensitivity, as well as HPA axis feedback sensitivity under stress in men and women. DESIGN/SUBJECTS/MEASUREMENTS: We assessed in 92 men and 102 women (18-55 years, BMI 19-41 kg/m(2) ) anthropometry, body composition using hydrodensitometry and deuterium dilution method, cortisol variability by measuring 5-h cortisol concentrations, HPA axis feedback functioning using a dexamethasone suppression test and HPA axis functioning under a challenged condition consisting of a standardized high intensity test with ingestion of 4 mg dexamethasone.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1365-2265
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
© 2011 Blackwell Publishing Ltd.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
74
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
679-86
|
|
pubmed:meshHeading |
pubmed-meshheading:21521257-Adolescent,
pubmed-meshheading:21521257-Adult,
pubmed-meshheading:21521257-Anti-Inflammatory Agents,
pubmed-meshheading:21521257-Body Composition,
pubmed-meshheading:21521257-Body Height,
pubmed-meshheading:21521257-Body Mass Index,
pubmed-meshheading:21521257-Body Weight,
pubmed-meshheading:21521257-Dexamethasone,
pubmed-meshheading:21521257-Exercise Test,
pubmed-meshheading:21521257-Female,
pubmed-meshheading:21521257-Gene Frequency,
pubmed-meshheading:21521257-Genotype,
pubmed-meshheading:21521257-Humans,
pubmed-meshheading:21521257-Hydrocortisone,
pubmed-meshheading:21521257-Hypothalamo-Hypophyseal System,
pubmed-meshheading:21521257-Linkage Disequilibrium,
pubmed-meshheading:21521257-Male,
pubmed-meshheading:21521257-Middle Aged,
pubmed-meshheading:21521257-Pituitary-Adrenal System,
pubmed-meshheading:21521257-Polymorphism, Single Nucleotide,
pubmed-meshheading:21521257-Pro-Opiomelanocortin,
pubmed-meshheading:21521257-Receptors, Glucocorticoid,
pubmed-meshheading:21521257-Regression Analysis,
pubmed-meshheading:21521257-Waist-Hip Ratio,
pubmed-meshheading:21521257-Young Adult
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Associations between anthropometrical measurements, body composition, single-nucleotide polymorphisms of the hypothalamus/pituitary/adrenal (HPA) axis and HPA axis functioning.
|
|
pubmed:affiliation |
Department of Human Biology, Maastricht University, Maastricht, The Netherlands. f.rutters@hb.unimaas.nl
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial
|
