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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-27
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|
pubmed:abstractText |
Tegafur is primarily converted to 5-fluorouracil (5-FU) by CYP2A6 in the human liver to exert its antitumor effect. Our objective was to comprehensively investigate the effects of CYP2A6 genetic polymorphisms on tegafur bioactivation activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1744-8042
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
481-92
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pubmed:meshHeading |
pubmed-meshheading:21521021-Adolescent,
pubmed-meshheading:21521021-Adult,
pubmed-meshheading:21521021-Alleles,
pubmed-meshheading:21521021-Antimetabolites, Antineoplastic,
pubmed-meshheading:21521021-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:21521021-Child,
pubmed-meshheading:21521021-Female,
pubmed-meshheading:21521021-Fluorouracil,
pubmed-meshheading:21521021-Genotype,
pubmed-meshheading:21521021-Haplotypes,
pubmed-meshheading:21521021-Humans,
pubmed-meshheading:21521021-Male,
pubmed-meshheading:21521021-Microsomes, Liver,
pubmed-meshheading:21521021-Middle Aged,
pubmed-meshheading:21521021-Polymorphism, Genetic,
pubmed-meshheading:21521021-Tegafur,
pubmed-meshheading:21521021-Young Adult
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|
pubmed:year |
2011
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|
pubmed:articleTitle |
Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes.
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pubmed:affiliation |
National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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