Linked Life Data

21517521

Source:http://linkedlifedata.com/resource/pubmed/id/21517521

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
2011-4-26
pubmed:abstractText
Almost two decades ago, measurements of force versus extension on isolated double-stranded DNA molecules revealed a force plateau. This unusual stretching phenomenon in DNA suggests that the long molecules may be extended from the usual B form into a new conformation. Different models have been proposed to describe the nature of DNA in its stretched form, S-DNA. Using atomic force microscopy combined with a molecular combing method, we identified the structure of ?-phage DNA for different stretching values. We provide strong evidence for the existence of a first-order transition between B form and S form. Beyond a certain extension of the natural length, DNA molecules adopt a new double-helix conformation characterized by a diameter of 1.2 nm and a helical pitch of 18 nm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1550-2376
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
031903
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Secondary structure of double-stranded DNA under stretching: elucidation of the stretched form.
pubmed:affiliation
Institut Charles Sadron, CNRS, University of Strasbourg, 23 rue du Loess, BP 84087, F-67034 Strasbourg Cedex 2, France. mounir.maaloum@ics-cnrs.unistra.fr
pubmed:publicationType
Journal Article