Linked Life Data

2151598

Source:http://linkedlifedata.com/resource/pubmed/id/2151598

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1991-8-9
pubmed:abstractText
Experiments were performed to delineate the mechanism by which tetanus toxoid (TT) suppresses the immune response. A CD4+ cell has been shown to suppress the PHA response (18). TT suppresses the phytohemagglutinin (PHA) blastogenic response and pokeweed mitogen (PWM) induction of IgM and IgG in a dose-dependent fashion. The suppression is partially reversed by indomethacin or interleukin-2. The tumor necrosis factor had no effect. TT induced the suppression within 36 h and the immunosuppressive activity induced could downregulate the response of fresh syngeneic cultures of peripheral blood leucocytes. We conclude that TT can induce nonspecific suppressor cells that can dampen mitogen responses which has important implications in the development and usage of vaccines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0171-2985
pubmed:author
pubmed:issnType
Print
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
345-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of IL-2 and indomethacin on the activation of suppressor cells induced by tetanus toxoid.
pubmed:affiliation
Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada.
pubmed:publicationType
Journal Article, In Vitro