Source:http://linkedlifedata.com/resource/pubmed/id/21515063
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2011-5-9
|
| pubmed:abstractText |
We discovered novel peroxisome proliferator-activated receptor ? agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPAR? transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates that this potential drug may be effective for the treatment of demyelinating disorders such as multiple sclerosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1464-3391
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3255-64
|
| pubmed:meshHeading |
pubmed-meshheading:21515063-Animals,
pubmed-meshheading:21515063-Cell Differentiation,
pubmed-meshheading:21515063-Cell Line,
pubmed-meshheading:21515063-Cells, Cultured,
pubmed-meshheading:21515063-Cerebral Cortex,
pubmed-meshheading:21515063-Humans,
pubmed-meshheading:21515063-Isoxazoles,
pubmed-meshheading:21515063-Oligodendroglia,
pubmed-meshheading:21515063-PPAR delta,
pubmed-meshheading:21515063-Rats,
pubmed-meshheading:21515063-Rats, Wistar
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Biological evaluation of novel benzisoxazole derivatives as PPAR? agonists.
|
| pubmed:affiliation |
Discovery Research Laboratories, Nippon Chemiphar Co. Ltd, Hikokawado, Misato, Saitama, Japan. sakuma@os.rim.or.jp
|
| pubmed:publicationType |
Journal Article
|