Source:http://linkedlifedata.com/resource/pubmed/id/21511938
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2011-4-22
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| pubmed:abstractText |
The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the treatment of congenital pseudarthrosis of the tibia has been investigated in only one previous study, with promising results. The aim of this study was to determine whether rhBMP-2 might improve the outcome of this disorder. We reviewed the medical records of five patients with a mean age of 7.4 years (2.3 to 21) with congenital pseudarthrosis of the tibia who had been treated with rhBMP-2 and intramedullary rodding. Ilizarov external fixation was also used in four of these patients. Radiological union of the pseudarthrosis was evident in all of them at a mean of 3.5 months (3.2 to 4) post-operatively. The Ilizarov device was removed after a mean of 4.2 months (3.0 to 5.3). These results indicate that treatment of congenital pseudarthrosis of the tibia using rhBMP-2 in combination with intramedullary stabilisation and Ilizarov external fixation may improve the initial rate of union and reduce the time to union. Further studies with more patients and longer follow-up are necessary to determine whether this surgial procedure may significantly enhance the outcome of congenital pseudarthrosis of the tibia, considering the refracture rate (two of five patients) in this small case series.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human bone...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0301-620X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
93
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
695-9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:21511938-Ankle Joint,
pubmed-meshheading:21511938-Bone Morphogenetic Protein 2,
pubmed-meshheading:21511938-Bone Morphogenetic Proteins,
pubmed-meshheading:21511938-Child, Preschool,
pubmed-meshheading:21511938-Combined Modality Therapy,
pubmed-meshheading:21511938-External Fixators,
pubmed-meshheading:21511938-Female,
pubmed-meshheading:21511938-Follow-Up Studies,
pubmed-meshheading:21511938-Fracture Fixation, Intramedullary,
pubmed-meshheading:21511938-Fracture Healing,
pubmed-meshheading:21511938-Humans,
pubmed-meshheading:21511938-Ilizarov Technique,
pubmed-meshheading:21511938-Knee Joint,
pubmed-meshheading:21511938-Male,
pubmed-meshheading:21511938-Pseudarthrosis,
pubmed-meshheading:21511938-Range of Motion, Articular,
pubmed-meshheading:21511938-Recombinant Proteins,
pubmed-meshheading:21511938-Retrospective Studies,
pubmed-meshheading:21511938-Tibial Fractures,
pubmed-meshheading:21511938-Transforming Growth Factor beta,
pubmed-meshheading:21511938-Treatment Outcome,
pubmed-meshheading:21511938-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Combined treatment of congenital pseudarthrosis of the tibia, including recombinant human bone morphogenetic protein-2: a case series.
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| pubmed:affiliation |
Department of Pediatric Orthopaedic Surgery, Children's Hospital, Hamburg, Germany. aspiro@uke.uni-hamburg.de
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| pubmed:publicationType |
Journal Article,
Evaluation Studies
|