Linked Life Data

21510978

Source:http://linkedlifedata.com/resource/pubmed/id/21510978

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-5-23
pubmed:abstractText
?-adrenoceptor stimulation can enhance the storage function of the urinary bladder by acting on detrusor smooth muscle tone, mediator release from the urothelium and/or afferent nerve activity. In humans this may occur predominantly if not exclusively via the ??-subtype. The effects of ?-adrenoceptor agonists including several ??-selective agonists have been studied in vitro and in vivo, in healthy animals of both genders and various age groups and in a wide range of animal (mostly rat) models of genetic or acquired bladder dysfunction. Such models included bladder irritation by intravesical instillation of acetic acid or prostaglandin E?, bladder outlet obstruction, stroke, diabetes, spontaneously hypertensive rats, and NO synthase inhibition. Across all of these models ?-adrenoceptor agonists had effects consistent with improved bladder storage function. ??-adrenoceptor effects are resistant to agonist-induced desensitization in many cell types, but whether this also applies to the human bladder is unknown. The efficacy of ?-adrenoceptor agonists appears to be largely unaffected by common polymorphisms of the ??-adrenoceptor gene. Taken together these findings suggest that ??-adrenoceptor agonists may become useful drugs for the treatment of bladder storage dysfunction, a view supported by recent phase III clinical studies for one such agent, mirabegron.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1879-016X
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
?-adrenoceptor agonist effects in experimental models of bladder dysfunction.
pubmed:affiliation
Dept. Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands. martincmichel@yahoo.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't