Linked Life Data

21509781

Source:http://linkedlifedata.com/resource/pubmed/id/21509781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-27
pubmed:abstractText
The aim of the present work was to decipher the cellular basis of the immunoregulatory role of peroxisome proliferator-activated receptor (PPAR)-? in cutaneous hypersensitivity reactions. After challenge with a contact allergen, we observed augmented hypersensitivity reactions with increased numbers of activated T lymphocytes in the skin of PPAR-?-/- mice. Furthermore, following antigen challenge, the percentages of Tregs in the blood, draining lymph nodes and skin were decreased in these mice. PPAR-? deficiency impaired the production of IL-2 in lymph nodes, whereas TGF-? levels remained unchanged. Injection of IL-2 into PPAR-?-/- mice restored the Treg population in the skin-draining lymph nodes of allergen-challenged mice. In vivo induction of Tregs from WT CD4+ CD25- T cells was impaired when adoptively transferred into PPAR-?-/- mice as compared with transfer into WT mice, and reversed by injection of IL-2 into PPAR-?-/- mice. Furthermore, the suppressive capacity of PPAR-?-/- Tregs was impaired when compared to WT Tregs in vitro and in co-adoptive transfer experiments. Finally, injection of IL-2 to PPAR-?-/- mice decreased skin inflammation to a level similar to WT mice. In conclusion, the pro-inflammatory skin phenotype of PPAR-?-/- mice is due to lack of IL-2-mediated Treg induction in these mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1521-4141
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1980-91
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Lack of IL-2 in PPAR-?-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells.
pubmed:affiliation
Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria. sandrine.dubrac@i-med.ac.at
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't