Linked Life Data

21508095

Source:http://linkedlifedata.com/resource/pubmed/id/21508095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-6-15
pubmed:abstractText
Folliculostellate (FS) cells in the anterior pituitary gland are believed to have multifunctional properties. Using transgenic rats that express green fluorescent protein (GFP) specifically in FS cells in the anterior pituitary gland (S100b-GFP rats), we recently revealed that FS cells in primary culture exhibited marked proliferation in the presence of laminin, an extracellular matrix (ECM) component of the basement membrane. In a process referred to as matricrine action, FS cells receive ECM as a signal through their receptors, which results in morphological and functional changes. In this study, we investigated matricrine signaling in FS cells and observed that the proliferation of FS cells is mediated by integrin ?1, which is involved in various signaling pathways for cell migration and proliferation in response to ECM. Then, we analyzed downstream events of the integrin ?1 signaling pathway in the proliferation of FS cells and identified caveolin 3 as a potential candidate molecule. Caveolin 3 is a membrane protein that binds cholesterol and a number of signaling molecules that interact with integrin ?1. Using specific small interfering RNA of caveolin 3, the proliferation of FS cells was inhibited. Furthermore, caveolin 3 drove activation of the mitogen-activated protein kinase (MAPK) signaling cascades, which resulted in upregulation of cyclin D1 in FS cells. These findings suggest that matricrine signaling in the proliferation of FS cells was transduced by a caveolin 3-mediated integrin ?1 signaling pathway and subsequent activation of the MAPK pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1479-6805
pubmed:author
pubmed:copyrightInfo
© 2011 Society for Endocrinology
pubmed:issnType
Electronic
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-36
pubmed:meshHeading
pubmed-meshheading:21508095-Animals, pubmed-meshheading:21508095-Antigens, CD29, pubmed-meshheading:21508095-Caveolae, pubmed-meshheading:21508095-Caveolin 1, pubmed-meshheading:21508095-Caveolin 3, pubmed-meshheading:21508095-Cell Polarity, pubmed-meshheading:21508095-Cell Proliferation, pubmed-meshheading:21508095-Cells, Cultured, pubmed-meshheading:21508095-Culture Techniques, pubmed-meshheading:21508095-Extracellular Matrix, pubmed-meshheading:21508095-Gene Silencing, pubmed-meshheading:21508095-Genes, Reporter, pubmed-meshheading:21508095-Laminin, pubmed-meshheading:21508095-MAP Kinase Signaling System, pubmed-meshheading:21508095-Male, pubmed-meshheading:21508095-Microscopy, Video, pubmed-meshheading:21508095-Nerve Growth Factors, pubmed-meshheading:21508095-Pituitary Gland, Anterior, pubmed-meshheading:21508095-RNA, Messenger, pubmed-meshheading:21508095-RNA, Small Interfering, pubmed-meshheading:21508095-Rats, pubmed-meshheading:21508095-Rats, Transgenic, pubmed-meshheading:21508095-S100 Proteins
pubmed:year
2011
pubmed:articleTitle
Caveolin 3-mediated integrin ?1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix.
pubmed:affiliation
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. kota@jichi.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't