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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-20
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pubmed:abstractText |
Spinocerebellar ataxias (SCAs) constitute a group of autosomal dominant neurodegenerative disorders with no current treatment. The insulin/insulin-like growth factor 1 (IGF-1) system (IIS) has been shown to play a role in the neurological dysfunction of SCAs and other polyglutamine disorders. We aimed to study the biomarker profile of serum IIS components in SCA3. We performed a case-control study with 46 SCA3 patients and 42 healthy individuals evaluating the peripheral IIS profile (insulin, IGF-1, IGFBP1 and 3) and the correlation with clinical, molecular, and neuroimaging findings. SCA3 patients presented lower insulin and IGFBP3 levels and higher insulin sensitivity (HOMA2), free IGF-I, and IGFBP1 levels when compared with controls. IGFBP-1 levels were directly associated with CAG expanded repeat length; IGF-1 was associated with the volumetries of specific brainstem regions on magnetic resonance imaging (MRI). Insulin levels and sensitivity were related to age at onset of symptoms. Our findings indicate an involvement of IIS components in SCA3 neurobiology and IGFBP-1 as a potential biomarker of the disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATXN3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IGFBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IGFBP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1531-8257
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pubmed:author |
pubmed-author:ArpaJavierJ,
pubmed-author:HanselGiseleG,
pubmed-author:JardimLaura BannachLB,
pubmed-author:MaedaFábioF,
pubmed-author:MullerAlexandre PastorisAP,
pubmed-author:PortelaLuis Valmor CruzLV,
pubmed-author:Saraiva-PereiraMaria LuizaML,
pubmed-author:SauteJonas Alex MoralesJA,
pubmed-author:SouzaDiogo OnofreDO,
pubmed-author:Torres-AlemanIgnacioI,
pubmed-author:VedolinLeonardoL,
pubmed-author:da SilvaAndrew Chaves FeitosaAC,
pubmed-author:de MelloAlexandre SilvaAS
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pubmed:copyrightInfo |
Copyright © 2010 Movement Disorder Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
731-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21506152-Adult,
pubmed-meshheading:21506152-Case-Control Studies,
pubmed-meshheading:21506152-Female,
pubmed-meshheading:21506152-Humans,
pubmed-meshheading:21506152-Insulin,
pubmed-meshheading:21506152-Insulin-Like Growth Factor Binding Protein 1,
pubmed-meshheading:21506152-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:21506152-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:21506152-Insulin-Like Growth Factor I,
pubmed-meshheading:21506152-Machado-Joseph Disease,
pubmed-meshheading:21506152-Male,
pubmed-meshheading:21506152-Middle Aged,
pubmed-meshheading:21506152-Nerve Tissue Proteins,
pubmed-meshheading:21506152-Nuclear Proteins,
pubmed-meshheading:21506152-Repressor Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Serum insulin-like system alterations in patients with spinocerebellar ataxia type 3.
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pubmed:affiliation |
Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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