Linked Life Data

21506151

Source:http://linkedlifedata.com/resource/pubmed/id/21506151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-20
pubmed:abstractText
The aim of this study was to test the hypothesis of a fundamental impairment of vocal pace performance in Parkinson's disease (PD) based on a syllable repetition paradigm and the influence of levodopa and deep brain stimulation of the subthalamic nucleus (STN-DBS). Twenty-two PD patients under stable dopaminergic medication, 14 patients with STN-DBS, and 30 controls were tested. Participants had to repeat the syllable /pa/ in a steady pace. Percental coefficient of variance (COV) of interval length was measured for the description of pace stability. Patients were tested in the OFF state and again in the ON state after levodopa administration or ongoing STN-DBS. COV was elevated in both PD subgroups. COV was not influenced by levodopa administration but showed a further deterioration under STN-DBS. The impaired syllable repetition capacity shows similarities to the patterns of more complex speech rhythm abnormalities in PD and therefore might share the same pathophysiology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1531-8257
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Movement Disorder Society.
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
728-30
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Instability of syllable repetition in Parkinson's disease--influence of levodopa and deep brain stimulation.
pubmed:affiliation
Department of Neurology, Knappschaftskrankenhaus, Ruhr-University of Bochum, Bochum, Germany. sabine.skodda@kk-bochum.de
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't