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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-30
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pubmed:abstractText |
Recent data suggest that a gene-environment interaction between smoking and the HLA shared epitope alleles plays a role in shaping the autoimmune reaction to specific citrullinated antigens. This study was undertaken to determine the effects of HLA shared epitope alleles and tobacco exposure on the immune response against various citrullinated antigens. These associations were analyzed in the anti-citrullinated protein antibody (ACPA)-positive stratum to control for the possibility that the associations found are explained by the known interaction between HLA shared epitope alleles and tobacco exposure on ACPA status.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1529-0131
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pubmed:author |
pubmed-author:GhideyWendimagegnW,
pubmed-author:Houwing-DuistermaatJeanine JJJ,
pubmed-author:HuizingaTom W JTW,
pubmed-author:LevarhtE W NivineEW,
pubmed-author:Stoeken-RijsbergenGerrieG,
pubmed-author:ToesRené E MRE,
pubmed-author:TrouwLeendert ALA,
pubmed-author:VerduynWillemW,
pubmed-author:WillemzeAnnemiekA,
pubmed-author:de VriesRené R PRR,
pubmed-author:van der WoudeDianeD
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pubmed:copyrightInfo |
Copyright © 2011 by the American College of Rheumatology.
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1823-32
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pubmed:meshHeading |
pubmed-meshheading:21506097-Adult,
pubmed-meshheading:21506097-Aged,
pubmed-meshheading:21506097-Alleles,
pubmed-meshheading:21506097-Arthritis, Rheumatoid,
pubmed-meshheading:21506097-Autoantibodies,
pubmed-meshheading:21506097-Autoimmunity,
pubmed-meshheading:21506097-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21506097-Epitopes,
pubmed-meshheading:21506097-Female,
pubmed-meshheading:21506097-Genetic Predisposition to Disease,
pubmed-meshheading:21506097-HLA Antigens,
pubmed-meshheading:21506097-Humans,
pubmed-meshheading:21506097-Immunoglobulin M,
pubmed-meshheading:21506097-Logistic Models,
pubmed-meshheading:21506097-Male,
pubmed-meshheading:21506097-Middle Aged,
pubmed-meshheading:21506097-Odds Ratio,
pubmed-meshheading:21506097-Risk Factors,
pubmed-meshheading:21506097-Smoking
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pubmed:year |
2011
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pubmed:articleTitle |
The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens.
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pubmed:affiliation |
Leiden University Medical Center, Leiden, The Netherlands. a.willemze@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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