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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-27
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pubmed:abstractText |
To identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2,890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P < 1 × 10(-5)) in the genome-wide association study were further genotyped in 673 cases and 2,596 controls. We found a previously unidentified locus in the 5' flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 × 10(-13), odds ratio = 1.39) to be strongly associated with HCV-induced HCC. Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 × 10(-8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 × 10(-13)).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:HosonoNaoyaN,
pubmed-author:KamataniNaoyukiN,
pubmed-author:KatoNaoyaN,
pubmed-author:KoikeKazuhikoK,
pubmed-author:KuboMichiakiM,
pubmed-author:KumarVinodV,
pubmed-author:MatsudaKoichiK,
pubmed-author:MuroyamaRyosukeR,
pubmed-author:NakagawaHidewakiH,
pubmed-author:NakamuraYusukeY,
pubmed-author:OmataMasaoM,
pubmed-author:OtsukaMotoyukiM,
pubmed-author:TakahashiAtsushiA,
pubmed-author:TateishiRyosukeR,
pubmed-author:UrabeYujiY
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
455-8
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pubmed:meshHeading |
pubmed-meshheading:21499248-Alcohol Drinking,
pubmed-meshheading:21499248-Carcinoma, Hepatocellular,
pubmed-meshheading:21499248-Case-Control Studies,
pubmed-meshheading:21499248-Disease Progression,
pubmed-meshheading:21499248-Female,
pubmed-meshheading:21499248-Genes, MHC Class I,
pubmed-meshheading:21499248-Genetic Predisposition to Disease,
pubmed-meshheading:21499248-Genome-Wide Association Study,
pubmed-meshheading:21499248-Hepatitis C, Chronic,
pubmed-meshheading:21499248-Histocompatibility Antigens Class I,
pubmed-meshheading:21499248-Humans,
pubmed-meshheading:21499248-Japan,
pubmed-meshheading:21499248-Liver Neoplasms,
pubmed-meshheading:21499248-Male,
pubmed-meshheading:21499248-Middle Aged,
pubmed-meshheading:21499248-Minisatellite Repeats,
pubmed-meshheading:21499248-Polymorphism, Single Nucleotide,
pubmed-meshheading:21499248-Quantitative Trait Loci,
pubmed-meshheading:21499248-Risk Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
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pubmed:affiliation |
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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